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Haffkine Biopharmaceutical Corpn. Ltd Profile

Contact Information
Company Name Haffkine Biopharmaceutical Corpn. Ltd
Contact Person
Address Acharya Donoe Marg, Parel
Mumbai, Maharashtra, India.
Zip / Postal Code 400 012
Telephone +91 - 22 - 24129320/363
Fax +91 - 22 - 24129323
Email Click here to email us
Company Info Company Profile


Under the Articles of Association of the Company, the Governor of Maharashtra is vested with the power to appoint all the Directors on the Board of the Company.

Haffkine Ajintha Pharmaceuticals Ltd., a subsidiary of Haffkine Bio-Pharmaceutical Corporation Ltd. , was established in 1977.
The Corporation plays a pioneering role in the development and production of a wide range of Bacterial and Viral vaccines for diphtheria, tetanus, whooping cough, plague, poliomyelitis and rabies.. The Corporation also formulates pharmaceutical products, disinfectants , ointments, injectables, syrups and mixtures.

The Antitoxin and Sera (ATS) department of HBPCL is located at Pimpri near Pune, and it is engaged in the manufacture of Antiserum against Tetanus, Diphtheria, Gas gangrene, Snake and Scorpion Venoms. The ATS department was established in 1940 at Mumbai for production of Anti Snake Venom Serum (ASVS) and subsequently shifted to Pimpri from 1952-53 onwards in a phased manner. The ATS dept operates on 75 acres of land and it is headed by Manager and assisted by different technical and nontechnical staff. The total staff strength at present is about 133. About 400 equines are also maintained to produce various antisera. The antisera are produced by HBPCL at most economical and affordable prices and are supplied mainly to various states and Central Government Institutions including defence.

            All the antisera are produced by hyperimmunising the equines by injecting gradually increasing doses of antigens (Venom/Toxin) over a period of 6 to 8 months. Once the equines attain a certain level of potency against the antigen, blood is collected in an anticoagulant solution from the equines every month and the blood is allowed to stand overnight. Next day the plasma is separated and the Red Blood Cells are reinfused into the body of equines (Plasmapheresis). The separated plasma that contains specific immunoglobulins is further processed by enzyme digestion and chemical separation to obtain purified equine immunoglobulins. The serum is tested for safety and potency on mice and then contenarised for distribution.

A Lyophilisation project confirming to WHO-GMP standards has been commissioned in the year 2002 and is being used for freeze drying of the antisera.

            The equines (Horses/Mules/Ponies) are used for the production of hyper immune serum for over hundred years, and it is a natural animal to choose due to certain advantages such as ease in handling, tolerance to repeated high doses of antigens, its ability to yield high volumes of blood at periodic intervals to mention a few. For HBPCL, the major source of Horses & mules has been the Indian Army, whereas ponies are procured locally from open market. Presently there are 362equines, however in the past ATS has maintained up to 800 equines.
HBPCL is the pioneer in the production of ASVS in India and has been producing it since 1940. Even the lyophilized ASVS has been introduced by HBPCL in the country since 1945. Earlier it used to be the largest manufacturer of ASVS in the country producing about 60 – 70% of the country’s total production. ASVS produced by HBPCL has even been exported to neighboring countries through WHO and UNICEF. The ATS dept. has produced over 4 lakh vials of ASVS during 1999-2000 and 2000-2001. However due to various restrictions imposed by CPCSEA on the use of equines in production of antisera, the production of ASVS has considerably reduced from 2001-2002 and has been producing about 1.5 lakh vials since last 4-5 years.

            In 1997, HBPCL was successful in introducing Scorpion Venom Antiserum for the first time in India, which was specifically developed to fulfill longstanding demand from Konkan region. Currently HBPCL is the only manufacturer of the same in the Country.

            From 1995 onwards, ATS dept is maintaining its own snake farm where three major poisonous snakes of India namely Cobra, Russell’s Viper, Common Krait are maintained to obtain venoms required hyperimmunisation of equines as per requirement.

            ATS dept also manufactures Anti Rabies Serum (ARS). Though, ARS is not new to HBPCL, since it did produce it long back, the consideration of restarting of ARS production is as per national needs as observed by Health Authorities, Govt. of India.

All the products manufactured at Pimpri are sent to Mumbai for marketing.

Haffkine Ajintha Pharmaceuticals Ltd., a subsidiary of Haffkine Bio-Pharmaceutical Corporation Ltd., has its manufacturing plant with modern facilities, located at Jalgaon and is engaged in manufacturing of tablets, capsules, ointments, powders and applications etc., which are mainly supplied to Hospitals/ Institutions of Govt. of Maharashtra.
Manufacturing and supply of quality health care products at reasonable prices.

   1. Qualitative manufacturing and timely supply of vaccine sera and other life saving drugs as per the needs of the society.
   2. Continuous upgradation of technology and GMP.
   3. Developing and sustaining competitive edge.
   4. Maintaining high level of employees motivatin and commitment.
   5. Managing the company's business and affairs in a self sustained manner.
   6. Ensuring a reasonable return on investment while effectively discharging social responsibilities.

Last Updated: 2009-09-04 06:16:28  

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Bulk Drugs / Intermediates of Haffkine Biopharmaceutical Corpn. Ltd

Ampicillin  69-53-4

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