Toxicological studies on methyl parathion with special reference to clinical signs, gross histopathological attributes in broilers

R.K. Misra, A.K. Misra* and P.K. Shukla
Department of Poultry Science College of Veterinary Science & A.H.,
Mathura - 281 001 (U.P.)

A biological trial was conducted to find out the effect of short-term administration of Methyl Parathion (25 or 50 ppm) insecticide in commercial broilers. The experiment was conducted for a period of 6 weeks from 2 nd to 7 th weeks of age. At 7 weeks of age one male and one female bird from each replicate group were slaughtered, PM was conducted and different visceral organs were collected for histopathological studies. The important symptoms of MPA toxicity were recorded as leg weakness and in coordination of movements. However these symptoms appeared in the group fed with 50 ppm of MPA during the last week of experimentation, as a result of it’s toxic property because of accumulative effect. The leg weakness and incoordinating movements were signs of preliminary stages of neuropathy. The gross pathological examination of internal organs revealed fragile and hemorrhagic liver with enlarged gall bladder, enlargement and hemorrhages in the spleen. The kidney appeared to show inflammatory changes with severe congestion as nephritis. Hydropericarditis and atrophy of bursa were the other prominent lesions.

The histopathological studied in the present investigation revealed that the liver of the birds fed MPA showed necrotic foci in the hepatic parenchyma, hyperplasia of bile duct epithelium showing bile duct proliferation. Bursa of the birds fed MPA (50 ppm) revealed marked degeneration and depletion of lymphoid cells. Spleen in the 50 ppm MPA group showed presence of secondary lymphoid follicle in the spleen parenchyma and necrotic foci in the spleen tissue depleting in lymphoid tissue. Heart in the 50-ppm MPA group showed degenerative changes in myocardium and the lungs showed presence of serofibrinous exudates in the lumen along with consolidation of alveoli.

Source : IPSACON-2005

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