Lipid profile studies in experimentally induced cyclopiazonic acid and T-2 mycotoxicoses in broiler chicken

C. Balachandran1, P. Kamalavenkatesh and B. Murali Manohar
Department of Veterinary Pathology
1. Centralised Clinical Laboratory
Madras Veterinary College Chennai - 600 007

Forty, newly hatched, unsexed broiler chicks were fed diets containing 10 ppm cyclopiazonic acid (CPA) and 1 ppm T-2toxin (T 2) either individually or in combination for 28 days. Sera samples collected from six birds from each group were subjected fro lipid profile studies. The respective total cholesterol (TC), HDL, TC/HDL, triglycerides (TG), VLDL and LDL values for control, CPA, T-2 and CPA-T-2 were 174.7313.35, 232.4032.39, 145.5011.73 and 265.0220.21 mg/dL, 57.084.17, 34.974.17, 57.724.08 and 58.572.70 mg/dL, 2.9650.29, 6.6560.45, 2.5410.34 and 4.5260.30, 180.2210.02, 270.8221.84, 148.606.11 and 242.9024.34 mg/dL, 36.042.00, 54.154.37, 29.721.22 and 48.584.87 mg/dL, 79.319.59, 143.2823.83, 58.0613.58 and 157.8716.42 mg/dL. There was significant (P< 0.05) difference between the control and toxin fed birds for TC, HDL, TC/HDL, triglycerides (TG), VLDL and LDL. Hypocholesterolaemia, hypotriglyceridaemia and low VLDL, and LDL were found in T-2 group when compared to the control group. Hypercholesterolaemia, hypertriglyceridaemia, low HDL and high TC/HDL, VLDL and LDL were recorded in CPA and CPA-T-2 groups when compared to the control group. The study indicated the lipid profiles could be altered by mycotoxins CPA and T-2 either alone or in combination in broiler chicks.

Source : IPSACON-2005

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